| LDR | | 02052nmm uu200409 4500 |
| 001 | | 000000332159 |
| 005 | | 20240805170141 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438239340 |
| 035 | |
▼a (MiAaPQ)AAI10954445 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 615 |
| 100 | 1 |
▼a Setiawan, Nico. |
| 245 | 10 |
▼a Understanding the Thermodynamics and Oral Absorption Potential of Pharmaceutical Amorphous Solid Dispersions. |
| 260 | |
▼a [S.l.] :
▼b University of Kentucky.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 159 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Patrick J. Marsac. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Kentucky, 2018. |
| 520 | |
▼a Supersaturating drug delivery systems, such as amorphous solid dispersions (ASDs), have been used extensively to elevate the apparent solubility and oral bioavailability of poorly water-soluble drugs. However, despite the numerous examples of su |
| 520 | |
▼a Further, ASDs must dissolve after administration and maintain the intended supersaturation in the gastrointestinal (GI) tract during the GI transit time to achieve maximum oral absorption. In solution, the energetics advantage of the amorphous o |
| 520 | |
▼a 1. The relative thermodynamics magnitude of various processes with respect to the crystallization energy associated with amorphous drugs 2. The development of a practical tool to measure the thermodynamic activity of amorphous materials over its |
| 590 | |
▼a School code: 0102. |
| 650 | 4 |
▼a Pharmaceutical sciences. |
| 650 | 4 |
▼a Chemical engineering. |
| 690 | |
▼a 0572 |
| 690 | |
▼a 0542 |
| 710 | 20 |
▼a University of Kentucky.
▼b Pharmacy. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0102 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15001224
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |