| LDR | | 02256nmm uu200409 4500 |
| 001 | | 000000332111 |
| 005 | | 20240805170040 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438190627 |
| 035 | |
▼a (MiAaPQ)AAI10829391 |
| 035 | |
▼a (MiAaPQ)mayo:10497 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 576.6 |
| 100 | 1 |
▼a Kumar, Swati. |
| 245 | 10 |
▼a Sensing of HIV-1 by the Innate Immune System. |
| 260 | |
▼a [S.l.] :
▼b College of Medicine - Mayo Clinic.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 160 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Advisers: David Dingli |
| 502 | 1 |
▼a Thesis (Ph.D.)--College of Medicine - Mayo Clinic, 2018. |
| 520 | |
▼a TREX1, a major mammalian exonuclease, has been reported to degrade cytosolic immune-stimulatory DNA, including viral DNA generated during HIV-1 infection, but the dynamic range of its capacity to suppress innate immune stimulation is unknown, wh |
| 520 | |
▼a The nearly complete lack of innate immune induction despite equal to increased viral integration observed when the TREX1 protein level is experimentally elevated indicates that integration-competent genomes are shielded from cytosolic sensor-eff |
| 520 | |
▼a In the second part of this thesis, we investigate how perturbations of the intricately linked early post entry events of reverse transcription and uncoating and remodeling of viral cores affect sensing of viral nucleic acids. Reverse transcripti |
| 520 | |
▼a Taken together, our studies showed that the PAMPs sensed after viral entry contain DNA, are TREX1 and cGAS substrates, and are derived from incomplete reverse transcription products. In contrast, the experiments demonstrated that full-length int |
| 590 | |
▼a School code: 1542. |
| 650 | 4 |
▼a Virology. |
| 690 | |
▼a 0720 |
| 710 | 20 |
▼a College of Medicine - Mayo Clinic.
▼b Virology and Gene Therapy. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 1542 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999300
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |