| LDR | | 02402nmm uu200457 4500 |
| 001 | | 000000331967 |
| 005 | | 20240805165737 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438169364 |
| 035 | |
▼a (MiAaPQ)AAI10826099 |
| 035 | |
▼a (MiAaPQ)umn:19283 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574.191 |
| 100 | 1 |
▼a Bohl, Thomas E. |
| 245 | 10 |
▼a Structural Studies of Two Enzymes in the Raetz Pathway of Lipid A Aynthesis, LpxB and LpxH. |
| 260 | |
▼a [S.l.] :
▼b University of Minnesota.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 178 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Hideki Aihara. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Minnesota, 2018. |
| 520 | |
▼a Gram-negative bacteria are distinguished from Gram-positive bacteria by the secondary membrane that surrounds their peptidoglycan cell wall. The outer leaflet of this membrane is primarily composed of the glycolipid lipopolysaccharide (LPS), whi |
| 520 | |
▼a Lipid A is synthesized in the well characterized and largely conserved Raetz pathway in the cytosol and at the cytosolic face of the inner membrane. The non-repeating core oligosaccharide is synthesized on lipid A the cytoplasmic face of the inn |
| 520 | |
▼a LpxH was crystallized with the alpha-helical substrate-binding cap domain in a displaced conformation, suggesting that this domain is highly mobile. The structural dynamics of this domain and their relevance to substrate binding were further exp |
| 520 | |
▼a In addition, the first structure of LpxB was determined showing a Glycosyltransferase B superfamily (GT-B) fold modified by the formation of a novel C-terminally swapped dimer wherein the last 87 residues of one subunit complete the GT-B fold of |
| 590 | |
▼a School code: 0130. |
| 650 | 4 |
▼a Biophysics. |
| 650 | 4 |
▼a Biochemistry. |
| 650 | 4 |
▼a Microbiology. |
| 690 | |
▼a 0786 |
| 690 | |
▼a 0487 |
| 690 | |
▼a 0410 |
| 710 | 20 |
▼a University of Minnesota.
▼b Biochemistry, Molecular Biology, and Biophysics. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0130 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998845
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |