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020 ▼a 9780438030428
035 ▼a (MiAaPQ)AAI10826617
035 ▼a (MiAaPQ)ucla:16854
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0820 ▼a 610
1001 ▼a Landers, Angelia C.
24510 ▼a Fully Automated Radiation Therapy Treatment Planning through Knowledge-based Dose Predictions.
260 ▼a [S.l.] : ▼b University of California, Los Angeles., ▼c 2018
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2018
300 ▼a 143 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
500 ▼a Adviser: Ke Sheng.
5021 ▼a Thesis (Ph.D.)--University of California, Los Angeles, 2018.
520 ▼a Intensity-modulated radiotherapy treatment planning is an inverse problem that typically includes numerous parameters that have to be manually tuned by expert planners. This process can take hours or even days and can often lead to suboptimal pl
520 ▼a Knowledge-based planning (KBP) dose prediction provides patient-specific estimations for the capabilities and limitations of a plan. Statistical voxel dose learning (SVDL) was developed to predict the voxel dose of new patients. The method was c
520 ▼a To remove any dependence on hyperparameters that require manual tuning, voxel-based non-coplanar 4pi radiotherapy and coplanar volumetric modulated arc therapy (VMAT) optimization problems were modified to include the KBP predicted doses. The ne
520 ▼a In the case of no existing high quality training set, evolving-knowledge-base (EKB) planning was developed. An initial, low quality training set was used for the first epoch of automated planning. In subsequent epochs, the superior plans from th
520 ▼a Through the course of this work, we established a robust and accurate KBP dose prediction technique, which we then utilized in our automated planning protocol. Both the use of high quality training sets and EKB planning created high quality plan
590 ▼a School code: 0031.
650 4 ▼a Biomedical engineering.
690 ▼a 0541
71020 ▼a University of California, Los Angeles. ▼b Biomedical Physics 0119.
7730 ▼t Dissertation Abstracts International ▼g 79-10B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0031
791 ▼a Ph.D.
792 ▼a 2018
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998911 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자