| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000331819 |
| 005 | | 20241120150427 |
| 008 | | 181129s2018 ||| | | | eng d |
| 020 | |
▼a 9780438065871 |
| 035 | |
▼a (MiAaPQ)AAI10825760 |
| 035 | |
▼a (MiAaPQ)unc:17927 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 616.079 |
| 100 | 1 |
▼a Chen, Liang. |
| 245 | 14 |
▼a The Innate Regulatory Protein NLRP12 Maintains Commensal Bacterial Symbiosis, and Mitigates Intestinal Inflammation and Obesity. |
| 260 | |
▼a [S.l.] :
▼b The University of North Carolina at Chapel Hill.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 181 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Advisers: Jenny P-Y. Ting |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018. |
| 520 | |
▼a The nucleotide-binding domain, leucine-rich repeat containing proteins, also known as NOD-like receptors (NLRs), are pattern recognition receptors that play important roles in innate immunity (Aganna et al., 2002 |
| 520 | |
▼a Members of the NLR family can be categorized into two groups, the inflammasome-forming and non-inflammasome-forming NLRs. Inflammasomes are cytoplasmic multi-protein complexes that result in the catalytic cleavage of procaspase-1, generating cas |
| 520 | |
▼a NLRP12, a negative regulator of innate immunity, suppresses colon inflammation and inflammation-driven colorectal cancer (Allen et al., 2012b |
| 520 | |
▼a In the second part, we extended our knowledge of NLRP12 to diet induced obesity. We found NLRP12 expression was lower in patients with higher body mass index (BMI), and Nlrp12--/-- mice were more susceptible to high-fat-diet (HFD) induced obesit |
| 590 | |
▼a School code: 0153. |
| 650 | 4 |
▼a Immunology. |
| 650 | 4 |
▼a Microbiology. |
| 690 | |
▼a 0982 |
| 690 | |
▼a 0410 |
| 710 | 20 |
▼a The University of North Carolina at Chapel Hill.
▼b Microbiology and Immunology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0153 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998802
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |