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020 ▼a 9780438065871
035 ▼a (MiAaPQ)AAI10825760
035 ▼a (MiAaPQ)unc:17927
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0820 ▼a 616.079
1001 ▼a Chen, Liang.
24514 ▼a The Innate Regulatory Protein NLRP12 Maintains Commensal Bacterial Symbiosis, and Mitigates Intestinal Inflammation and Obesity.
260 ▼a [S.l.] : ▼b The University of North Carolina at Chapel Hill., ▼c 2018
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2018
300 ▼a 181 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
500 ▼a Advisers: Jenny P-Y. Ting
5021 ▼a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018.
520 ▼a The nucleotide-binding domain, leucine-rich repeat containing proteins, also known as NOD-like receptors (NLRs), are pattern recognition receptors that play important roles in innate immunity (Aganna et al., 2002
520 ▼a Members of the NLR family can be categorized into two groups, the inflammasome-forming and non-inflammasome-forming NLRs. Inflammasomes are cytoplasmic multi-protein complexes that result in the catalytic cleavage of procaspase-1, generating cas
520 ▼a NLRP12, a negative regulator of innate immunity, suppresses colon inflammation and inflammation-driven colorectal cancer (Allen et al., 2012b
520 ▼a In the second part, we extended our knowledge of NLRP12 to diet induced obesity. We found NLRP12 expression was lower in patients with higher body mass index (BMI), and Nlrp12--/-- mice were more susceptible to high-fat-diet (HFD) induced obesit
590 ▼a School code: 0153.
650 4 ▼a Immunology.
650 4 ▼a Microbiology.
690 ▼a 0982
690 ▼a 0410
71020 ▼a The University of North Carolina at Chapel Hill. ▼b Microbiology and Immunology.
7730 ▼t Dissertation Abstracts International ▼g 79-10B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0153
791 ▼a Ph.D.
792 ▼a 2018
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998802 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자