| LDR | | 02078nmm uu200421 4500 |
| 001 | | 000000331745 |
| 005 | | 20240805165257 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438367012 |
| 035 | |
▼a (MiAaPQ)AAI10934234 |
| 035 | |
▼a (MiAaPQ)wisc:15775 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Cho, Eunjin. |
| 245 | 10 |
▼a Molecular Pathways in Heart Development and Disease. |
| 260 | |
▼a [S.l.] :
▼b The University of Wisconsin - Madison.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 164 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Youngsook Lee. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2018. |
| 520 | |
▼a Jarid2 (Jumonji A/T-rich interaction domain 2) is an essential factor for normal heart development. Deletion of Jarid2 in mice results in cardiac malformations recapitulating human congenital cardiac disease, and dysregulation of gene expression |
| 520 | |
▼a Interestingly, deletion of Jarid2 by alpha MHC-Cre (Jarid2alphaMHC) resulted in complete lethality by 9 months of age with dilated cardiomyopathy. Jarid2alphaMHC mice showed an increase in fetal gene expression, such as Tnni1 and Acta2 at neon |
| 520 | |
▼a These studies reveal the critical roles of Jarid2 in the myocardial development. Jarid2 is necessary to establish correct epigenetics on the target genomic loci during a narrow developmental window, which is prior to differentiation of cardiac p |
| 590 | |
▼a School code: 0262. |
| 650 | 4 |
▼a Developmental biology. |
| 650 | 4 |
▼a Biology. |
| 690 | |
▼a 0758 |
| 690 | |
▼a 0306 |
| 710 | 20 |
▼a The University of Wisconsin - Madison.
▼b Molecular & Cellular Pharmacology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0262 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15001175
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |