| LDR | | 02405nmm uu200433 4500 |
| 001 | | 000000331740 |
| 005 | | 20240805165251 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438359758 |
| 035 | |
▼a (MiAaPQ)AAI10934129 |
| 035 | |
▼a (MiAaPQ)wisc:15767 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 310 |
| 100 | 1 |
▼a Welch, Rene. |
| 245 | 10 |
▼a Statistical Methods for Chip-Exo/Nexus Quality Control, and Fine-mapping of Multi-trait SNPs in High LD by Using Next-generation Sequencing Data. |
| 260 | |
▼a [S.l.] :
▼b The University of Wisconsin - Madison.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 110 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Sunduz Keles. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2018. |
| 520 | |
▼a Advances in the field of genomics over the last years have led to diverse types of measurements with vast amounts of next generation sequencing (NGS) data. As genomic measurements become faster and cheaper with higher-throughput technologies, la |
| 520 | |
▼a In this thesis we introduce two methods. First, we present ChIPexoQual, an R/Bioconductor quality control pipeline that enables exploration and analysis of ChIP-exo and related experiments. ChIPexoQual evaluates a number of key issues including |
| 520 | |
▼a Next, we introduce FM-HighLD, a fine-mapping method for variants in high linkage disequilibrium that, by using ChIP-seq based annotation data, is capable of calculating SNP probabilities for being causal for single or multiple traits by using an |
| 520 | |
▼a Finally, in this thesis, we showcase two R/Bioconductor packages to facilitate the analysis of next generation sequencing data, and explore RNA-seq differential expression results. First, ChIPUtils is a package that calculates typical ChIP-seq q |
| 590 | |
▼a School code: 0262. |
| 650 | 4 |
▼a Statistics. |
| 650 | 4 |
▼a Bioinformatics. |
| 690 | |
▼a 0463 |
| 690 | |
▼a 0715 |
| 710 | 20 |
▼a The University of Wisconsin - Madison.
▼b Statistics. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0262 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15001170
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |