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020 ▼a 9780438359680
035 ▼a (MiAaPQ)AAI10934010
035 ▼a (MiAaPQ)wisc:15755
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0820 ▼a 574
1001 ▼a Franco, Sarah.
24510 ▼a Investigation of the Role of FOXM1 in the Development of Intimal Hyperplasia.
260 ▼a [S.l.] : ▼b The University of Wisconsin - Madison., ▼c 2018
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2018
300 ▼a 127 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
500 ▼a Adviser: Bo Liu.
5021 ▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2018.
520 ▼a Vascular smooth muscle cell (SMC) proliferation and survival are key contributors to the initiation and progression of vascular diseases including restenosis. Forkhead Box M1 (FOXM1) is a proliferation-associated transcription factor shown to pl
520 ▼a In Chapter 2, we utilize the rat carotid balloon injury model to characterize the expression of FOXM1 in the vascular wall. To the best of our knowledge, we are the first to report an upregulation of FOXM1 in neointimal SMCs following balloon in
520 ▼a In sum, the data generated in my thesis provide foundational evidence that FOXM1 is an important player in SMC response to vascular injury as well as SMC viability. With further understanding of the mechanistic role of FOXM1 in vascular diseases
590 ▼a School code: 0262.
650 4 ▼a Cellular biology.
650 4 ▼a Pathology.
650 4 ▼a Molecular biology.
690 ▼a 0379
690 ▼a 0571
690 ▼a 0307
71020 ▼a The University of Wisconsin - Madison. ▼b Cellular & Molecular Pathology.
7730 ▼t Dissertation Abstracts International ▼g 80-01B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0262
791 ▼a Ph.D.
792 ▼a 2018
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T15001163 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자