| LDR | | 02644nmm uu200421 4500 |
| 001 | | 000000331717 |
| 005 | | 20240805165222 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438414594 |
| 035 | |
▼a (MiAaPQ)AAI10933567 |
| 035 | |
▼a (MiAaPQ)ucla:17203 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 616 |
| 100 | 1 |
▼a Tribble, Jennifer Elizabeth. |
| 245 | 10 |
▼a Characterizing the Behavioral and Neural Mechanisms Underpinning Stress-enhanced Fear Learning, a Rodent Model of Post-traumatic Stress Disorder. |
| 260 | |
▼a [S.l.] :
▼b University of California, Los Angeles.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 162 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-02(E), Section: B. |
| 500 | |
▼a Adviser: Michael Fanselow. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of California, Los Angeles, 2018. |
| 520 | |
▼a Post-Traumatic Stress Disorder (PTSD) is a complex, multi-faceted disease that affects a subset of individuals who undergo a traumatic experience. To understand the variety of psychological symptoms and their underpinning neural mechanisms, our |
| 520 | |
▼a In Chapter 2, I test for the effects of pair housing animals prior to, during, and following the acute stressor. Rodents are extremely social animals, and isolation housing has been shown to magnify or sufficiently cause effects of stress. There |
| 520 | |
▼a In Chapter 3, I test for the role of kappa opioid receptors (KORs) in the subsequent expression of PTSD-like phenotypes following an acute stressor. The KOR antagonist JDTic was administered immediately after trauma, then animals were tested for |
| 520 | |
▼a In Chapter 4, I use a variety of techniques to assess the neural mechanisms underlying the enhanced fear phenotype observed in our PTSD model. Specifically, I test for changes in excitatory receptors expressed in brain regions associated with fe |
| 520 | |
▼a Collectively, these studies serve as a beginning of exploring the many behavioral and neural mechanisms underlying our rodent model of PTSD. Future and subsequent studies may build off of this work to further characterize the PTSD-like phenotype |
| 590 | |
▼a School code: 0031. |
| 650 | 4 |
▼a Neurosciences. |
| 690 | |
▼a 0317 |
| 710 | 20 |
▼a University of California, Los Angeles.
▼b Neuroscience 004F. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-02B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0031 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15001147
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |