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020 ▼a 9780438286658
035 ▼a (MiAaPQ)AAI10928560
035 ▼a (MiAaPQ)grad.msu:16267
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0820 ▼a 616
1001 ▼a Duffy, Megan Frances.
24514 ▼a The Temporal Relationship between Synucleinopathy, Nigrostriatal Degeneration, and Neuroinflammation in the Alpha-Synuclein Preformed Fibril Model of Parkinson's Disease.
260 ▼a [S.l.] : ▼b Michigan State University., ▼c 2018
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2018
300 ▼a 195 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
500 ▼a Adviser: Caryl E. Sortwell.
5021 ▼a Thesis (Ph.D.)--Michigan State University, 2018.
520 ▼a Numerous studies have documented risk variants in immune genes and increased microglial inflammatory markers in the parenchyma and biofluids of Parkinson's disease (PD) patients. Recently our lab has characterized a new rat model of PD induced b
520 ▼a First, I histologically examined the time course of synucleinopathy, microgliosis and nigral degeneration at monthly intervals. Microglia in the vicinity of Lewy body-like inclusions display significantly increased cell body area and observable
590 ▼a School code: 0128.
650 4 ▼a Neurosciences.
690 ▼a 0317
71020 ▼a Michigan State University. ▼b Neuroscience - Doctor of Philosophy.
7730 ▼t Dissertation Abstracts International ▼g 79-12B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0128
791 ▼a Ph.D.
792 ▼a 2018
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000907 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자