| LDR | | 02929nmm uu200481 4500 |
| 001 | | 000000331458 |
| 005 | | 20240805164425 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438269071 |
| 035 | |
▼a (MiAaPQ)AAI10928052 |
| 035 | |
▼a (MiAaPQ)wisc:15587 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 541 |
| 100 | 1 |
▼a Mohapatra, Sonisilpa. |
| 245 | 10 |
▼a Functional Mapping of the Components of the E. coli Translational Machinery. |
| 260 | |
▼a [S.l.] :
▼b The University of Wisconsin - Madison.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 210 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: James Carl Weisshaar. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2018. |
| 520 | |
▼a Bacterial cells generally lack membrane-bound organelles. Therefore, traditionally they were viewed as bags of freely diffusing macromolecules devoid of any internal organization. The development in imaging techniques in the last two decades has |
| 520 | |
▼a Most cellular processes are regulated by complex networks of intermolecular interactions. A systematic study quantifying the correlation in spatial organization of various biomolecules might help to unravel their underlying interactions. A posit |
| 520 | |
▼a Translation is one of the most important cellular process. Ribosomes are the central component of translation engaged in protein synthesis from mRNA. Optimal usage of ribosomes is dependent on their spatial organization. In this dissertation, th |
| 520 | |
▼a In rapidly growing E. coli and B. subtilis, strong nucleoid -- ribosome segregation is observed. The picture of spatial organization in slowly growing C. crescentus is however completely different. The effect of growth rate on the segregation of |
| 520 | |
▼a In cells, the translation elongation is discontinuous, often suffering from periods of pauses. The cells have mechanisms to alleviate these pauses, irrespective of the reason for pausing. EF-P is a translation factor that alleviates pausing duri |
| 520 | |
▼a Overall, the reported works explore the synergism of interactions between different components of translation and their spatiotemporal organization. The famous biologist Jacques Monod noted "What was true for the E. coli would be true for the e |
| 590 | |
▼a School code: 0262. |
| 650 | 4 |
▼a Physical chemistry. |
| 650 | 4 |
▼a Biophysics. |
| 650 | 4 |
▼a Chemistry. |
| 690 | |
▼a 0494 |
| 690 | |
▼a 0786 |
| 690 | |
▼a 0485 |
| 710 | 20 |
▼a The University of Wisconsin - Madison.
▼b Chemistry. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0262 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000877
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |