| LDR | | 02791nmm uu200469 4500 |
| 001 | | 000000331395 |
| 005 | | 20240805164310 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438193505 |
| 035 | |
▼a (MiAaPQ)AAI10917780 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Gaines, Jennifer Christine. |
| 245 | 10 |
▼a Computational Studies of Protein Structure. |
| 260 | |
▼a [S.l.] :
▼b Yale University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 101 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. |
| 500 | |
▼a Adviser: Corey S. O'Hern. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Yale University, 2018. |
| 520 | |
▼a Although much is known about the experimentally measurable properties of individual proteins, we do not have a solid understanding of the universal properties that control protein structure and stability. The amount of protein crystal structure |
| 520 | |
▼a My work, building on prior protein structural studies, uses the new plethora of protein crystal structure data to develop a deeper understanding of the physical properties of proteins. I focus on using an atomistic model of proteins, involving s |
| 520 | |
▼a This dissertation presents three related computational studies of the properties of protein structures. In the first study, I present an analysis of the packing fraction of protein cores. I show that protein cores are composed of random close pa |
| 520 | |
▼a I then take a more detailed look at protein cores to quantify the amount of side chain dihedral angle movement possible in the core. To do this, I apply a hard-sphere model with stereochemical constraints to rotate the side chain dihedral angles |
| 520 | |
▼a Finally, I expand both of these studies to two other protein types: protein-protein interfaces and transmembrane proteins. For both datasets, I investigate the packing fraction and side chain predictability of both core and solvent exposed amino |
| 520 | |
▼a This thesis work challenges the commonly accepted properties of protein structure, in particular that proteins have a high packing fraction similar to crystalline packing of spheres and that transmembrane proteins are fundamentally different fro |
| 590 | |
▼a School code: 0265. |
| 650 | 4 |
▼a Bioinformatics. |
| 650 | 4 |
▼a Biophysics. |
| 650 | 4 |
▼a Computational physics. |
| 690 | |
▼a 0715 |
| 690 | |
▼a 0786 |
| 690 | |
▼a 0216 |
| 710 | 20 |
▼a Yale University. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-11B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0265 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000815
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |