| LDR | | 02051nmm uu200397 4500 |
| 001 | | 000000331318 |
| 005 | | 20240805164139 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438342866 |
| 035 | |
▼a (MiAaPQ)AAI10841672 |
| 035 | |
▼a (MiAaPQ)uab:12401 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 616.079 |
| 100 | 1 |
▼a Shin, Boyoung. |
| 245 | 10 |
▼a Regulation of Effector CD4 T Cell Pathogenicity during Chronic Inflammation. |
| 260 | |
▼a [S.l.] :
▼b The University of Alabama at Birmingham.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 148 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Laurie E. Harrington. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Alabama at Birmingham, 2018. |
| 520 | |
▼a Effector CD4 T cells are essential for the balance between pro- and anti-inflammatory immune responses during homeostasis. Dysregulation of effector CD4 T cell responses results in chronic inflammatory disorders such as Inflammatory Bowel Diseas |
| 520 | |
▼a Different subsets of effector CD4 T cells utilize distinct metabolic pathways. We find that Th17 differentiation occurs in conjunction with a robust increase of ATP-linked mitochondrial respiration, which fuels energy demand. Interestingly, mito |
| 520 | |
▼a We also find that the differentiation state of CD4 T cells contributes to pathogenicity. A transcriptome analysis of effector CD4 T cells from chronic intestinal inflammation reveals that CD4 T cells exist as a spectrum of differentiation states |
| 590 | |
▼a School code: 0005. |
| 650 | 4 |
▼a Immunology. |
| 690 | |
▼a 0982 |
| 710 | 20 |
▼a The University of Alabama at Birmingham.
▼b Joint Health Sciences. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0005 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999798
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |