| LDR | | 02016nmm uu200397 4500 |
| 001 | | 000000331246 |
| 005 | | 20240805164013 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438200944 |
| 035 | |
▼a (MiAaPQ)AAI10840446 |
| 035 | |
▼a (MiAaPQ)wisc:15524 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 575 |
| 100 | 1 |
▼a Macke, Erica Lynn. |
| 245 | 10 |
▼a Identifying Genetic Factors Involved in Aging and Neurodegeneration. |
| 260 | |
▼a [S.l.] :
▼b The University of Wisconsin - Madison.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 174 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Akihiro Ikeda. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2018. |
| 520 | |
▼a The broad objective of my research is to understand the onset and progression of aging and age-related diseases. By studying the normal aging process, as well as mutants exhibiting abnormal aging phenotypes, we can elucidate the mechanisms invol |
| 520 | |
▼a First, I utilized two inbred mouse lines that show differences in the rate of retinal aging in order to elucidate the molecular mechanisms of the aging process. It has been shown that an inbred strain, A/J, is susceptible to age-dependent retina |
| 520 | |
▼a Next, we found that a spontaneous mutant mouse line, small with kinky tail (skt), exhibits accelerated aging phenotypes. We have identified age-dependent retinal abnormalities including retinal degeneration, hippocampal neurodegeneration, increa |
| 590 | |
▼a School code: 0262. |
| 650 | 4 |
▼a Genetics. |
| 690 | |
▼a 0369 |
| 710 | 20 |
▼a The University of Wisconsin - Madison.
▼b Genetics. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0262 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999726
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |