| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000331244 |
| 005 | | 20241114164539 |
| 008 | | 181129s2018 ||| | | | eng d |
| 020 | |
▼a 9780438377455 |
| 035 | |
▼a (MiAaPQ)AAI10840439 |
| 035 | |
▼a (MiAaPQ)duke:14839 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 310 |
| 100 | 1 |
▼a Larson, Gary J. |
| 245 | 10 |
▼a Advances in Bayesian Modeling of Protein Structure Evolution. |
| 260 | |
▼a [S.l.] :
▼b Duke University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 143 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-02(E), Section: B. |
| 500 | |
▼a Adviser: Scott C. Schmidler. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Duke University, 2018. |
| 520 | |
▼a This thesis contributes to a statistical modeling framework for protein sequence and structure evolution. An existing Bayesian model for protein structure evolution is extended in two unique ways. Each of these model extensions addresses an impo |
| 520 | |
▼a Most available models for protein structure evolution do not model interdependence between the backbone sites of the protein, yet the assumption that the sites evolve independently is known to be false. I argue that ignoring such dependence lead |
| 520 | |
▼a The second model expansion allows for evolutionary inference on protein pairs having structural discrepancies attributable to backbone flexion. Thus, the model expansion exposes flexible protein structures to the capabilities of Bayesian protein |
| 520 | |
▼a Finally, I present work related to the study of bias in site-independent models for sequence evolution. In the case of binary sequences, I discuss strategies for theoretical proof of bias and provide various details to that end, including detail |
| 590 | |
▼a School code: 0066. |
| 650 | 4 |
▼a Statistics. |
| 650 | 4 |
▼a Biology. |
| 690 | |
▼a 0463 |
| 690 | |
▼a 0306 |
| 710 | 20 |
▼a Duke University.
▼b Statistical Science. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-02B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0066 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999724
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |