| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000331112 |
| 005 | | 20241108153151 |
| 008 | | 181129s2018 ||| | | | eng d |
| 020 | |
▼a 9780438149014 |
| 035 | |
▼a (MiAaPQ)AAI10837913 |
| 035 | |
▼a (MiAaPQ)wisc:15498 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 612 |
| 100 | 1 |
▼a Tsao, Tzu-Wei. |
| 245 | 10 |
▼a Uncovering Structural Mechanisms Underlying GABA-A Receptor Activation and Drug Modulation. |
| 260 | |
▼a [S.l.] :
▼b The University of Wisconsin - Madison.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 182 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. |
| 500 | |
▼a Adviser: Cynthia Czajkowski. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2018. |
| 520 | |
▼a Gamma-aminobutyric acid type A receptors (GABAARs) are pentameric ligand-gated ion channels (pLGICs) that mediate neuronal inhibition in the brain. Defects in GABAAR signaling are associated with a variety of neurological diseases and psychiatri |
| 520 | |
▼a In this thesis, I used the substituted cysteine accessibility method and two-electrode voltage clamp electrophysiology in Xenopus laevis oocytes to demonstrate that orthosteric and allosteric non-competitive agonists stabilize the same open cha |
| 520 | |
▼a The results in this thesis provide new information about structural mechanisms underlying GABAAR activation and allosteric drug modulation. These data will provide useful information on targeting subunit interfaces in allosteric proteins for nov |
| 590 | |
▼a School code: 0262. |
| 650 | 4 |
▼a Physiology. |
| 650 | 4 |
▼a Biophysics. |
| 690 | |
▼a 0719 |
| 690 | |
▼a 0786 |
| 710 | 20 |
▼a The University of Wisconsin - Madison.
▼b Neuroscience. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-11B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0262 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999592
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |