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020 ▼a 9780438117693
035 ▼a (MiAaPQ)AAI10831060
035 ▼a (MiAaPQ)mayo:10504
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0491 ▼f DP
0820 ▼a 574
1001 ▼a Chen, Xiaoyue.
24510 ▼a Epigenetic Abnormalities in Brain Tumors.
260 ▼a [S.l.] : ▼b College of Medicine - Mayo Clinic., ▼c 2018
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2018
300 ▼a 125 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
500 ▼a Advisers: Zhiguo Zhang
5021 ▼a Thesis (Ph.D.)--College of Medicine - Mayo Clinic, 2018.
520 ▼a Epigenetics is the study of heritable changes that alters gene expression without changing DNA sequence. Previous studies showed that epigenetic alterations were associated with tumor initiation, progression and the development of chemo-resistan
520 ▼a MGMT promoter methylation is one of the most important glioblastoma biomarkers. Hypermethylation of this promoter is associated with a lower MGMT expression and a higher efficacy of TMZ therapy. However, MGMT promoter methylation state does not
520 ▼a Besides the development of resistance, epigenetic alterations play an important role in the initiation of DIPG. However, whether epigenetic alterations can be targeted to treat DIPG is unknown. In Chapter III, I show that inhibiting histone deme
590 ▼a School code: 1542.
650 4 ▼a Biology.
650 4 ▼a Oncology.
650 4 ▼a Molecular biology.
690 ▼a 0306
690 ▼a 0992
690 ▼a 0307
71020 ▼a College of Medicine - Mayo Clinic. ▼b Biochemistry and Molecular Biology.
7730 ▼t Dissertation Abstracts International ▼g 79-11B(E).
773 ▼t Dissertation Abstract International
790 ▼a 1542
791 ▼a Ph.D.
792 ▼a 2018
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999494 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자 ▼b 관리자