| LDR | | 02008nmm uu200397 4500 |
| 001 | | 000000330952 |
| 005 | | 20240805163132 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438115552 |
| 035 | |
▼a (MiAaPQ)AAI10830418 |
| 035 | |
▼a (MiAaPQ)wisc:15448 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Jones, Elaina K. |
| 245 | 14 |
▼a The Role of D52 in Acinar Homeostasis. |
| 260 | |
▼a [S.l.] :
▼b The University of Wisconsin - Madison.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 123 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. |
| 500 | |
▼a Adviser: Guy E. Groblewski. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2018. |
| 520 | |
▼a D52 is a cytosolic, peripheral membrane associated protein that binds a number of membrane trafficking associated proteins and is highly expressed in pancreatic acinar cells. Work by the Groblewski lab has identified a role for D52 in regulating |
| 520 | |
▼a Pancreatitis induces acinar cell dedifferentiation to a duct-like exocrine progenitor state as a mechanism of recovery. The dedifferentiated progenitors proliferate to repopulate the gland before differentiating back into acinar cells under the |
| 520 | |
▼a In Chapter four, we utilized an inducible model of acinar specific D52 deletion (D52--/--) to investigate the impact of losing D52 expression, an early event in the onset of pancreatitis. Loss of D52 alone caused significant acinar cell damage, |
| 590 | |
▼a School code: 0262. |
| 650 | 4 |
▼a Cellular biology. |
| 690 | |
▼a 0379 |
| 710 | 20 |
▼a The University of Wisconsin - Madison.
▼b Nutritional Sciences. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-11B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0262 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999431
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |