| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000330912 |
| 005 | | 20241105175457 |
| 008 | | 181129s2016 ||| | | | eng d |
| 020 | |
▼a 9780438134508 |
| 035 | |
▼a (MiAaPQ)AAI10903625 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 576 |
| 100 | 1 |
▼a Biryukov, Sergei Sergeievich. |
| 245 | 10 |
▼a Complement and Antibody-Mediated Enhancement of Red Blood Cell Invasion by Plasmodium Falciparum. |
| 260 | |
▼a [S.l.] :
▼b The Pennsylvania State University.,
▼c 2016 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2016 |
| 300 | |
▼a 215 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Pennsylvania State University, 2016. |
| 520 | |
▼a Plasmodium falciparum malaria is responsible for close to one million deaths worldwide each year. The Plasmodium life cycle involves invasion of hepatocytes and erythrocytes. The repeating cycle of erythrocyte invasion and destruction is the roo |
| 520 | |
▼a We hypothesize that complement activation and opsonization of merozoites enhances complement receptor 1 (CR1)-mediated invasion of erythrocytes. If we are correct, the parasite can hijack this arm of the innate immune response for its own benefi |
| 520 | |
▼a In addition, we utilized erythrocytes from individuals with paroxysmal nocturnal hemoglobinuria (PNH), which results in the absence of glycosylphosphatidylinositol (GPI)-anchored receptors, in an effort to identify novel receptors utilized by th |
| 520 | |
▼a Our results demonstrate that merozoites can highjack the complement system to their own advantage in a number of ways. Activation of the complement cascade via the classical pathway can allow merozoites to bind to CR1 and invade via this pathway |
| 590 | |
▼a School code: 0176. |
| 650 | 4 |
▼a Microbiology. |
| 650 | 4 |
▼a Immunology. |
| 650 | 4 |
▼a Parasitology. |
| 690 | |
▼a 0410 |
| 690 | |
▼a 0982 |
| 690 | |
▼a 0718 |
| 710 | 20 |
▼a The Pennsylvania State University.
▼b Microbiology and Immunology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0176 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2016 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000628
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |