| LDR | | 02043nmm uu200421 4500 |
| 001 | | 000000330904 |
| 005 | | 20240805163037 |
| 008 | | 181129s2016 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438134348 |
| 035 | |
▼a (MiAaPQ)AAI10903609 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 540 |
| 100 | 1 |
▼a Acevedo, Roderico. |
| 245 | 10 |
▼a Investigation of Protein-RNA Interactions of the TAR-RNA Binding Protein (TRBP). |
| 260 | |
▼a [S.l.] :
▼b The Pennsylvania State University.,
▼c 2016 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2016 |
| 300 | |
▼a 207 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Pennsylvania State University, 2016. |
| 520 | |
▼a Post-transcriptional regulation of gene expression is dependent on multiple RNA silencing pathways, termed generally as RNA interference (RNAi). Silencing occurs through use of single-stranded RNAs, produced as double-stranded precursors, in two |
| 520 | |
▼a TRBP contains 3 double-stranded RNA binding domains (dsRBDs). Here, we focus on the first two dsRBDs, which have been shown to bind dsRNA. By monitoring the binding affinity of the first two dsRBDs of TRBP individually (TRBP-dsRBD1 and TRBP-dsRB |
| 520 | |
▼a Further inspection of TRBP-DeltaC's binding thermodynamics using isothermal titration calorimetry revealed that changing the linker length between dsRBDs modulates TRBP-DeltaC binding affinity. Jacobson-Stockmayer analysis of the linker length d |
| 590 | |
▼a School code: 0176. |
| 650 | 4 |
▼a Chemistry. |
| 650 | 4 |
▼a Biochemistry. |
| 650 | 4 |
▼a Biophysics. |
| 690 | |
▼a 0485 |
| 690 | |
▼a 0487 |
| 690 | |
▼a 0786 |
| 710 | 20 |
▼a The Pennsylvania State University.
▼b Chemistry. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0176 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2016 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000619
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |