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008181129s2016 ||| | | | eng d
020 ▼a 9780438134348
035 ▼a (MiAaPQ)AAI10903609
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0491 ▼f DP
0820 ▼a 540
1001 ▼a Acevedo, Roderico.
24510 ▼a Investigation of Protein-RNA Interactions of the TAR-RNA Binding Protein (TRBP).
260 ▼a [S.l.] : ▼b The Pennsylvania State University., ▼c 2016
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2016
300 ▼a 207 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
5021 ▼a Thesis (Ph.D.)--The Pennsylvania State University, 2016.
520 ▼a Post-transcriptional regulation of gene expression is dependent on multiple RNA silencing pathways, termed generally as RNA interference (RNAi). Silencing occurs through use of single-stranded RNAs, produced as double-stranded precursors, in two
520 ▼a TRBP contains 3 double-stranded RNA binding domains (dsRBDs). Here, we focus on the first two dsRBDs, which have been shown to bind dsRNA. By monitoring the binding affinity of the first two dsRBDs of TRBP individually (TRBP-dsRBD1 and TRBP-dsRB
520 ▼a Further inspection of TRBP-DeltaC's binding thermodynamics using isothermal titration calorimetry revealed that changing the linker length between dsRBDs modulates TRBP-DeltaC binding affinity. Jacobson-Stockmayer analysis of the linker length d
590 ▼a School code: 0176.
650 4 ▼a Chemistry.
650 4 ▼a Biochemistry.
650 4 ▼a Biophysics.
690 ▼a 0485
690 ▼a 0487
690 ▼a 0786
71020 ▼a The Pennsylvania State University. ▼b Chemistry.
7730 ▼t Dissertation Abstracts International ▼g 79-12B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0176
791 ▼a Ph.D.
792 ▼a 2016
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000619 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자 ▼b 관리자