| LDR | | 02249nmm uu200409 4500 |
| 001 | | 000000330882 |
| 005 | | 20240805163012 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438127029 |
| 035 | |
▼a (MiAaPQ)AAI10903096 |
| 035 | |
▼a (MiAaPQ)umichrackham:001181 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574.191 |
| 100 | 1 |
▼a Bourg, Julia Tofalo. |
| 245 | 10 |
▼a Investigation of Membrane Order within Integrin-Mediated Adhesion. |
| 260 | |
▼a [S.l.] :
▼b University of Michigan.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 108 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Sarah Veatch. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Michigan, 2018. |
| 520 | |
▼a Integrins are transmembrane adhesion receptors that engage ligands in the extracellular matrix and cytoskeletal proteins to form multi-protein adhesive complexes. These complexes provide a platform for integrin signaling and a mechanical anchor |
| 520 | |
▼a This dissertation investigates how integrins associate with membrane order through newly developed super-resolution imaging techniques that are capable of directly observing the local enrichment and depletion of peptide markers of liquid-ordered |
| 520 | |
▼a I find that beta1 integrins co-localize with both markers of membrane order and disorder across the plasma membrane. I find that affinity for a membrane ordered probe depends on activation state and that beta1 integrins from mature fibrillar adh |
| 520 | |
▼a The structure-function relationship of integrins has broad biological implications contributing to cell viability, growth, and motility. My work indicates that integrin association with membrane order is more subtle than previously proposed and |
| 590 | |
▼a School code: 0127. |
| 650 | 4 |
▼a Biophysics. |
| 690 | |
▼a 0786 |
| 710 | 20 |
▼a University of Michigan.
▼b Biophysics. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0127 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000590
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |