| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000330823 |
| 005 | | 20241105113631 |
| 008 | | 181129s2018 ||| | | | eng d |
| 020 | |
▼a 9780438126060 |
| 035 | |
▼a (MiAaPQ)AAI10903000 |
| 035 | |
▼a (MiAaPQ)umichrackham:001264 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 576.6 |
| 100 | 1 |
▼a McCrone, John T., IV. |
| 245 | 10 |
▼a Influenza Virus Evolution within and Between Human Hosts. |
| 260 | |
▼a [S.l.] :
▼b University of Michigan.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 173 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Adam Lauring. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Michigan, 2018. |
| 520 | |
▼a Rapid adaptive evolution significantly contributes to the size and severity of seasonal influenza epidemics. While influenza evolution has been well defined at the global scale, these dynamics ultimately derive from processes that take place wit |
| 520 | |
▼a In my thesis, I have applied an empirically-validated, next-generation sequencing approach to over 300 patient-derived samples from two vaccinated cohorts to define influenza evolution within and between naturally infected individuals. I compare |
| 520 | |
▼a In the second study, I used quantitative models to define influenza virus dynamics in individuals enrolled in a prospective, community-based cohort. Sequence data from 35 serially sampled individuals suggested that within-host populations are dy |
| 520 | |
▼a These data suggest that contrary to the global dynamics, positive selection is inefficient at the level of the individual host. Genetic drift and other stochastic processes likely dominate the host-level evolution of influenza viruses. |
| 590 | |
▼a School code: 0127. |
| 650 | 4 |
▼a Virology. |
| 690 | |
▼a 0720 |
| 710 | 20 |
▼a University of Michigan.
▼b Microbiology & Immunology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0127 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000508
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |