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020 ▼a 9780438126046
035 ▼a (MiAaPQ)AAI10902998
035 ▼a (MiAaPQ)umichrackham:001173
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0820 ▼a 610
1001 ▼a Pilipchuk, Sophia Patricia.
24510 ▼a Design of 3D-Printed, Micropatterned Scaffolds for Tissue Engineering of Bone-Ligament Constructs in the Oral Cavity using Gene Therapy.
260 ▼a [S.l.] : ▼b University of Michigan., ▼c 2018
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2018
300 ▼a 205 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
500 ▼a Adviser: William V. Giannobile.
5021 ▼a Thesis (Ph.D.)--University of Michigan, 2018.
520 ▼a Periodontitis is a leading chronic oral inflammatory disease and primary cause of permanent tooth loss estimated to affect 47.2% of adults in the United States. Damage to the tooth-supporting apparatus, which includes periodontal ligament (PDL)
520 ▼a Micropatterned polycaprolactone (PCL) films were designed to assess PDL cell orientation in vitro, with incorporation of the patterned film into a 3D-printed PCL scaffold for evaluation of varying topography on oriented tissue formation in an ec
520 ▼a In order to improve spatially-controlled delivery of BMP7 and platelet-derived growth factor (PDGF-BB) using developed 3D-printed, micropatterned scaffolds, each region of the scaffold was separately immobilized with AdBMP7 and AdPDGF-BB, respec
590 ▼a School code: 0127.
650 4 ▼a Biomedical engineering.
650 4 ▼a Genetics.
690 ▼a 0541
690 ▼a 0369
71020 ▼a University of Michigan. ▼b Biomedical Engineering.
7730 ▼t Dissertation Abstracts International ▼g 79-12B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0127
791 ▼a Ph.D.
792 ▼a 2018
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000506 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자