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020 ▼a 9780438125872
035 ▼a (MiAaPQ)AAI10902981
035 ▼a (MiAaPQ)umichrackham:001266
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0491 ▼f DP
0820 ▼a 616.079
1001 ▼a Taitano, Sophina Horne.
24510 ▼a Role of TH2 Cytokines in Regulatory B Cell Biology.
260 ▼a [S.l.] : ▼b University of Michigan., ▼c 2018
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2018
300 ▼a 129 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
500 ▼a Advisers: Nicholas W. Lukacs
5021 ▼a Thesis (Ph.D.)--University of Michigan, 2018.
520 ▼a B cells are now appreciated to be far more than antibody secreting cells. Throughout the last two decades B cells have been described to utilize a vast array of mechanisms to influence immune responses. Immune tolerance is achieved by a network
520 ▼a To understand how regulatory B cells are modulated during allergic responses, we investigated the effects of TH2 cytokines (IL-5 and IL-4) on their regulatory function and growth in vitro. Previously, the lab reported that culture with CD40 liga
520 ▼a Similar in vitro cultures were performed with human B cells from the peripheral blood. Inhibitors were used to target signaling pathways downstream of CD40L and IL-5 stimulation to understand the necessary pathways for regulatory B cells growth
520 ▼a Together this work provides insight into the modulation of regulatory B cells during allergic inflammation. We also identify possible targets to further investigate as therapeutics to enhance or inhibit regulatory B cell activity. Many protectiv
590 ▼a School code: 0127.
650 4 ▼a Immunology.
690 ▼a 0982
71020 ▼a University of Michigan. ▼b Immunology.
7730 ▼t Dissertation Abstracts International ▼g 79-12B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0127
791 ▼a Ph.D.
792 ▼a 2018
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000489 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자 ▼b 관리자