| LDR | | 02077nmm uu200397 4500 |
| 001 | | 000000330794 |
| 005 | | 20240805162830 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438125643 |
| 035 | |
▼a (MiAaPQ)AAI10902957 |
| 035 | |
▼a (MiAaPQ)umichrackham:001165 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574.191 |
| 100 | 1 |
▼a Woldemichael, Tehetina B. |
| 245 | 10 |
▼a Exploring Drug Bioaccumulation and Stabilization with Respect to Endolysosomal Ion Homeostasis Using a Systems-Based Mathematical Modeling Approach. |
| 260 | |
▼a [S.l.] :
▼b University of Michigan.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 216 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Advisers: Gustavo Rosania |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Michigan, 2018. |
| 520 | |
▼a Even though most of the FDA approved drugs currently out in the market and in the process of development are weakly basic drugs, the bioaccumulation and stabilization of these drugs are not well understood. For this purpose, we use a model drug, |
| 520 | |
▼a To test our hypothesis, we adapt a systems-based mathematical lysosomal ion regulation model, which consists of lysosomal membrane proteins, such as the proton-pump known as Vacuolar ATPase (V-ATPase), Cl-/H + antiporter known as CLC7, and membr |
| 520 | |
▼a Collectively, our computational results as well as the CFZ-H+ Cl- physicochemical properties in relation to the ion contents and pH of the microenvironment suggest that the physiological and preferential phase-transition-dependent accumulation a |
| 590 | |
▼a School code: 0127. |
| 650 | 4 |
▼a Biophysics. |
| 690 | |
▼a 0786 |
| 710 | 20 |
▼a University of Michigan.
▼b Biophysics. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0127 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000466
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |