| LDR | | 02247nmm uu200409 4500 |
| 001 | | 000000330785 |
| 005 | | 20240805162819 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438125384 |
| 035 | |
▼a (MiAaPQ)AAI10902931 |
| 035 | |
▼a (MiAaPQ)umichrackham:001175 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 530 |
| 100 | 1 |
▼a Kamgar-Parsi, Kian. |
| 245 | 10 |
▼a Amyloid Aggregation Behavior of Human Calcitonin. |
| 260 | |
▼a [S.l.] :
▼b University of Michigan.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 141 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Ayyalusamy Ramamoorthy. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Michigan, 2018. |
| 520 | |
▼a Under appropriate conditions, certain peptides and proteins, both intrinsically disordered and misfolded from their native state, can self-associate to form long proteinaceous fibrils known as amyloids. This transition forms the molecular basis |
| 520 | |
▼a A direct relationship between human calcitonin (hCT) concentration and aggregation lag time was observed for the first time, contrary to the conventional understanding of amyloid aggregation. This kinetic trend was found to persist over a range |
| 520 | |
▼a The determinants of hCT lag time were further investigated in a membrane environment, providing the first systematic study of the effect of membranes on CT aggregation. The direct relationship between peptide concentration and lag phase was foun |
| 520 | |
▼a The results of this thesis, particularly as they relate to monomer growth competence, represent significant contributions to the amyloid field and CT therapy. The novel kinetic mechanism proposed reveals that intramolecular interactions in disor |
| 590 | |
▼a School code: 0127. |
| 650 | 4 |
▼a Applied physics. |
| 690 | |
▼a 0215 |
| 710 | 20 |
▼a University of Michigan.
▼b Applied Physics. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0127 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000442
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |