| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000330694 |
| 005 | | 20241104143438 |
| 008 | | 181129s2017 ||| | | | eng d |
| 020 | |
▼a 9780438098794 |
| 035 | |
▼a (MiAaPQ)AAI10901941 |
| 035 | |
▼a (MiAaPQ)OhioLINK:osu1503199514997833 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 660 |
| 100 | 1 |
▼a Nabar, Gauri Mangesh. |
| 245 | 10 |
▼a Encapsulation of Nanoparticles and Polymers within Block Copolymer Micelles Prepared by the Emulsion and Solvent Evaporation Method. |
| 260 | |
▼a [S.l.] :
▼b The Ohio State University.,
▼c 2017 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2017 |
| 300 | |
▼a 316 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Advisers: Jessica Winter |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Ohio State University, 2017. |
| 520 | |
▼a Nearly 90% of drugs in the developmental stage and most high quality nanoparticles used in the detection and treatment of various medical conditions are poorly soluble in the aqueous physiological environment. This has led to a very high demand |
| 520 | |
▼a This dissertation covers the following broad areas: (1) encapsulation of polymers and nanoparticles into micelles (2) effect of process additives and external fields on micelle functionality (3) effect of processing conditions on micelle morphol |
| 520 | |
▼a Encapsulation studies: We found that the emulsion and solvent evaporation method could yield high encapsulation of polymers in micelles. We developed a unique hybrid micelle formulation for drug delivery by encapsulating high molecular weight po |
| 520 | |
▼a Additives and external fields: Surfactants used during micelle preparation had a surprising effect on the fluorescence of quantum dot loaded micelles. Surfactants that increased the density of the micelle coating around the encapsulated quantum |
| 520 | |
▼a External magnetic fields could impact the ordering of magnetic nanoparticles within micelles. This effect was even stronger when the external magnetic field was applied during the encapsulation of magnetic nanoparticles into micelles. |
| 520 | |
▼a Processing conditions: Altering the solvent evaporation rate dramatically influenced micelle morphology. Very low rates of solvent evaporation yielded nanoparticle loaded block copolymer nanoparticles with intricate internal geometries. |
| 520 | |
▼a Our studies show that the emulsion and solvent evaporation process is a highly tunable and robust process that can afford access to micelles with interesting morphologies and superior functionality. |
| 520 | |
▼a References: 1. Zhu, J. |
| 590 | |
▼a School code: 0168. |
| 650 | 4 |
▼a Chemical engineering. |
| 690 | |
▼a 0542 |
| 710 | 20 |
▼a The Ohio State University.
▼b Chemical Engineering. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0168 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000335
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |