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020 ▼a 9780438098480
035 ▼a (MiAaPQ)AAI10901909
035 ▼a (MiAaPQ)OhioLINK:osu1503248777003095
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0491 ▼f DP
0820 ▼a 616.01
1001 ▼a Kohart, Nicole Ann.
24510 ▼a Models, Mechanisms, and Treatment of Adult T-cell Leukemia/Lymphoma Bone Metastasis.
260 ▼a [S.l.] : ▼b The Ohio State University., ▼c 2017
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2017
300 ▼a 221 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
500 ▼a Adviser: Thomas Rosol.
5021 ▼a Thesis (Ph.D.)--The Ohio State University, 2017.
520 ▼a Adult T-cell Leukemia/Lymphoma (ATL) is a rapidly fatal hematological malignancy that develops in a subset of Human T-cell Leukemia Virus Type 1 (HTLV-1) carriers after a 20-40 year latency. ATL has a unique relationship to bone characterized by
520 ▼a Several animal models exist to study the pathogenesis of HTLV-1 and ATL
520 ▼a Elevated levels of bone acting factors PTHrP, interleukin-6 (IL-6), and macrophage inflammatory protein-1alpha (MIP-1alpha) are found in serum of patients with ATL. Studies have defined an endocrine role for these factors to act on osteoclasts a
520 ▼a To investigate new treatments for ATL bone metastases, we selected two agents that have demonstrated success in other bone-tropic neoplasms but have not been evaluated in ATL. Histone deacetylase inhibitors (HDACi) are a class of anti-cancer age
520 ▼a In this dissertation research, we established and characterized novel mouse models of ATL bone metastasis for preclinical and pathogenesis studies of ATL. We found several bone-acting factors expressed in ATL bone tumors, notably high PTHrP expr
590 ▼a School code: 0168.
650 4 ▼a Pathology.
690 ▼a 0571
71020 ▼a The Ohio State University. ▼b Comparative and Veterinary Medicine.
7730 ▼t Dissertation Abstracts International ▼g 79-12B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0168
791 ▼a Ph.D.
792 ▼a 2017
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000319 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자 ▼b 관리자