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008181129s2017 ||| | | | eng d
020 ▼a 9780438098022
035 ▼a (MiAaPQ)AAI10901861
035 ▼a (MiAaPQ)OhioLINK:osu1512028882555253
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0491 ▼f DP
0820 ▼a 574
1001 ▼a Heilman, Patrick Lawrence.
24510 ▼a Interrogating the Functional Consequences of Peripheral Neuropathy Associated Mutations in Heat Shock Protein B1.
260 ▼a [S.l.] : ▼b The Ohio State University., ▼c 2017
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2017
300 ▼a 173 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
500 ▼a Adviser: Stephen Kolb.
5021 ▼a Thesis (Ph.D.)--The Ohio State University, 2017.
520 ▼a Heat shock protein beta-1 (HSPB1), is a ubiquitously expressed, multifunctional protein chaperone that plays an important role in protein quality control, inflammation, apoptosis, cell growth and cytoskeleton maintenance. Mutations in HSPB1 resu
520 ▼a To elucidate a mechanism of HSPB1-mediated neuroprotection, I examined the role of wild-type and mutant HSPB1 in regulating inflammatory gene expression through activation of NF-kB signaling and mRNA decay apthways. Wild-type, but not mutant HSP
590 ▼a School code: 0168.
650 4 ▼a Biochemistry.
650 4 ▼a Neurosciences.
690 ▼a 0487
690 ▼a 0317
71020 ▼a The Ohio State University. ▼b Biochemistry.
7730 ▼t Dissertation Abstracts International ▼g 79-12B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0168
791 ▼a Ph.D.
792 ▼a 2017
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000295 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자 ▼b 관리자