| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000330647 |
| 005 | | 20241104113635 |
| 008 | | 181129s2015 ||| | | | eng d |
| 020 | |
▼a 9780438097643 |
| 035 | |
▼a (MiAaPQ)AAI10891796 |
| 035 | |
▼a (MiAaPQ)OhioLINK:osu1429031970 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 610 |
| 100 | 1 |
▼a Nelson, Mark Tyler. |
| 245 | 10 |
▼a Biomimetic Electrospun Fibers for Cancer Cell Migration, Chemotaxis, and Anti-Metastatic Drug Testing. |
| 260 | |
▼a [S.l.] :
▼b The Ohio State University.,
▼c 2015 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2015 |
| 300 | |
▼a 347 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: John Lannutti. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Ohio State University, 2015. |
| 520 | |
▼a Electrospun fibers are currently utilized in a wide range of biomedical and commercial applications. The unique microstructure and morphology of electrospun nanofibers produce nanoscale inter-fiber porosity and large surface areas that promote c |
| 520 | |
▼a In addition, electrospun fiber microstructure and morphology closely resembles and mimics the extracellular matrix (ECM) of human tissues and tumors. In my work, supercritical carbon dioxide (SCCO2) mediated infusion of small molecules |
| 520 | |
▼a Supercritical fluids present an approach capable of enhancing the chemical activity of composite tissue engineering scaffolds. Previous attempts to embed test compounds into electrospun polycaprolactone (PCL) alone at pressures above 6.20 MPa an |
| 520 | |
▼a High-throughput in vitro tools allowing rapid, accurate, and novel anti-metastatic drug screening are grossly overdue. Conversely, aligned nanofiber constitutes a prominent topographic component of the late-stage tumor margin extracellular matri |
| 520 | |
▼a Further investigation in the cellular and genetic mechanisms that enhance the ability of tumor cells to sense topographical and chemotactic cues will aid in determining novel targets for future anti-metastatic drug development. The reported work |
| 590 | |
▼a School code: 0168. |
| 650 | 4 |
▼a Biomedical engineering. |
| 650 | 4 |
▼a Cellular biology. |
| 650 | 4 |
▼a Materials science. |
| 690 | |
▼a 0541 |
| 690 | |
▼a 0379 |
| 690 | |
▼a 0794 |
| 710 | 20 |
▼a The Ohio State University.
▼b Biomedical Engineering. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0168 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2015 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000277
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |