| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000330645 |
| 005 | | 20241104113009 |
| 008 | | 181129s2015 ||| | | | eng d |
| 020 | |
▼a 9780438097421 |
| 035 | |
▼a (MiAaPQ)AAI10891779 |
| 035 | |
▼a (MiAaPQ)OhioLINK:osu1429637289 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 590 |
| 100 | 1 |
▼a Zhang, Jibin. |
| 245 | 10 |
▼a Identification of Important Cell Cycle Regulators and Novel Genes in Specific Tissues Using Microarray Analysis, Bioinformatics and Molecular Tools. |
| 260 | |
▼a [S.l.] :
▼b The Ohio State University.,
▼c 2015 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2015 |
| 300 | |
▼a 192 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Michael Davis. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Ohio State University, 2015. |
| 520 | |
▼a Study of cell cycle activity is critical to understand development of adipose tissue, because the switch on and off of cell cycle activity is tightly related to hyperplasia and hypotrophy of the fat cells. Three cell cycle inhibitors---CCNG2, CD |
| 520 | |
▼a The three important cell cycle inhibitors showed higher expression in fat cells than in preadipocytes and increased exprerssion during primary cell culture and development of adipose tissue in quantitative real-time PCR (qPCR) or western blottin |
| 520 | |
▼a In broiler chickens, expression of CCNG2, CDKN2C, CCND3 and ANAPC5 reaches a peak at post-hatch day 5 and decreases in the later stages, suggesting that day 5 may be an important time with active proliferation and differentiation of preadipocyte |
| 520 | |
▼a In the third experiment, some tissue specific secretory factors in mouse were selected based on GEO data analysis and bioinformatic tools. The tissue specific expressions of the selected genes were confirmed using semi-quantitative PCR. Secretio |
| 520 | |
▼a In the fourth study, a novel adipose specific gene HPS4 was revealed by DNA microarray analysis. Its higher expression in adipose tissue than in other tissues and in fat cells than in stromal vascular cells was detected by qPCR or western blotti |
| 520 | |
▼a In general, our studies not only developed a strategy to identify genes with important effects and novel genes in adipose and other tissues, but also increased our understanding about adipose tissue and provided some guidance to studies in other |
| 590 | |
▼a School code: 0168. |
| 650 | 4 |
▼a Zoology. |
| 650 | 4 |
▼a Bioinformatics. |
| 650 | 4 |
▼a Animal sciences. |
| 650 | 4 |
▼a Biology. |
| 690 | |
▼a 0472 |
| 690 | |
▼a 0715 |
| 690 | |
▼a 0475 |
| 690 | |
▼a 0306 |
| 710 | 20 |
▼a The Ohio State University.
▼b Animal Sciences. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0168 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2015 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000273
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |