| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000330603 |
| 005 | | 20241101155906 |
| 008 | | 181129s2016 ||| | | | eng d |
| 020 | |
▼a 9780438091207 |
| 035 | |
▼a (MiAaPQ)AAI10871340 |
| 035 | |
▼a (MiAaPQ)OhioLINK:osu1459777728 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 615 |
| 100 | 1 |
▼a Long, Victor Paul, III. |
| 245 | 10 |
▼a Modulation of the Arrhythmia Substrate in Cardiovascular Disease. |
| 260 | |
▼a [S.l.] :
▼b The Ohio State University.,
▼c 2016 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2016 |
| 300 | |
▼a 155 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Cynthia Carnes. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Ohio State University, 2016. |
| 520 | |
▼a Heart failure remains a leading cause of morbidity and mortality in the United States. Many of the deaths attributed to heart failure are sudden, presumably due to lethal arrhythmia. It is a combination of structural and electrical remodeling wi |
| 520 | |
▼a We found that heart failure duration is very important in the progressive reduction of the repolarization reserve of K+ currents in the ventricle. Our results differ from other models, as we were able to identify IKr reduction in chronic heart f |
| 520 | |
▼a Our chronic heart failure model was also used to investigate the role of adenosine-induced sinus node dysfunction in heart failure. Failing sinoatrial node cells had slower intrinsic firing rates versus normal control cells. We were able to dem |
| 520 | |
▼a Finally, we tested the performance of an algorithm designed to allow pharmacists to manage patient serum potassium levels in patients taking antiarrhytmic medications. Due to the high risk of proarrhythmia among this population, we established a |
| 520 | |
▼a We propose that these studies provide insights into the cellular bases for the development of heart failure-induced arrhythmias, as well as optimizing management of arrhythmia in a clinical setting. |
| 590 | |
▼a School code: 0168. |
| 650 | 4 |
▼a Pharmacology. |
| 690 | |
▼a 0419 |
| 710 | 20 |
▼a The Ohio State University.
▼b Pharmacy. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0168 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2016 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000207
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |