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020 ▼a 9780438071476
035 ▼a (MiAaPQ)AAI10868347
035 ▼a (MiAaPQ)OhioLINK:osu1509529255511222
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0491 ▼f DP
0820 ▼a 610
1001 ▼a Komar, Hannah M.
24510 ▼a Identifying Pathogenic Stromal and Acinar Signaling for Improved Diagnosis and Treatment of Chronic Pancreatitis.
260 ▼a [S.l.] : ▼b The Ohio State University., ▼c 2017
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2017
300 ▼a 174 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
500 ▼a Advisers: Gregory Lesinski
5021 ▼a Thesis (Ph.D.)--The Ohio State University, 2017.
520 ▼a Chronic pancreatitis (CP) is a devastating disease characterized by persistent inflammation and fibrosis of the pancreas leading to exocrine and endocrine insufficiency and increased risk of malignancy. Unfortunately, diagnosis of CP remains dif
520 ▼a We hypothesized that the pro-survival Jak2/STAT3 and MAPK pathways play a role in PSC activation and proliferation and that these pathways would serve as therapeutic targets to reduce the pathogenic activity of these cells during disease. In vit
520 ▼a To examine this hypothesis in vivo, we utilized the caerulein-induced murine model of chronic pancreatitis. Ruxolitinib was administered at 90mg/kg twice daily by oral gavage during the final week of caerulein treatment. Results show a trend tow
520 ▼a To develop an experimental method to identify novel therapeutic and diagnostic biomarkers for CP, we hypothesized that proteomic analysis of pancreatic tissue from the caerulein-induced murine model of CP would elucidate candidate biomarkers of
590 ▼a School code: 0168.
650 4 ▼a Biomedical engineering.
650 4 ▼a Immunology.
690 ▼a 0541
690 ▼a 0982
71020 ▼a The Ohio State University. ▼b Biomedical Sciences.
7730 ▼t Dissertation Abstracts International ▼g 79-10B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0168
791 ▼a Ph.D.
792 ▼a 2017
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000180 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자 ▼b 관리자