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008181129s2015 ||| | | | eng d
020 ▼a 9780438051409
035 ▼a (MiAaPQ)AAI10867755
035 ▼a (MiAaPQ)OhioLINK:osu1449218489
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0491 ▼f DP
0820 ▼a 574
1001 ▼a Hussein, Hayam.
24510 ▼a Cathepsin K Inhibition In Bone And Bone Marrow In Horses.
260 ▼a [S.l.] : ▼b The Ohio State University., ▼c 2015
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2015
300 ▼a 181 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
500 ▼a Adviser: Alicia Bertone.
5021 ▼a Thesis (Ph.D.)--The Ohio State University, 2015.
520 ▼a Cathepsin K (CatK), a cysteine protease, has been implicated in the process of bone resorption and inflammation. Selective inhibitors of CatK are promising therapeutic agents for the treatment of diseases associated with excessive bone loss and
520 ▼a In the first phase of this work, we determined an optimal dose and dose interval for a CatK inhibitor (CatKI), VEL-0230, in healthy adult horses. Plasma pharmacokinetic (PK) and bone resorption biomarker [carboxy-terminal cross-linking telopepti
520 ▼a In the second phase of this work, we evaluated bone structure and turnover in healthy young exercising horses receiving repeated oral dosing of a CatKI in a randomized, controlled, double-blinded, prospective, sufficiently powered clinical trial
520 ▼a In the third phase of this work, we compared the effects of in vivo CatKI administration for 4 weeks to control vehicle administration for 4 weeks on equine bone marrow-derived stem and progenitor cells. Bone marrow was harvested from the stern
520 ▼a In the fourth phase of work, we have studied two inflammatory models in equine bone marrow nucleated cells (BMNCs)
590 ▼a School code: 0168.
650 4 ▼a Cellular biology.
650 4 ▼a Biomedical engineering.
650 4 ▼a Biology.
690 ▼a 0379
690 ▼a 0541
690 ▼a 0306
71020 ▼a The Ohio State University. ▼b Comparative and Veterinary Medicine.
7730 ▼t Dissertation Abstracts International ▼g 79-10B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0168
791 ▼a Ph.D.
792 ▼a 2015
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000174 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자 ▼b 관리자