| LDR | | 01857nmm uu200385 4500 |
| 001 | | 000000330371 |
| 005 | | 20240805161330 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438361652 |
| 035 | |
▼a (MiAaPQ)AAI10844056 |
| 035 | |
▼a (MiAaPQ)purdue:23154 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 547 |
| 100 | 1 |
▼a Hostetler, Matthew A. |
| 245 | 10 |
▼a Part I. the Rational Design, Synthesis, and Evaluation of Second Generation Class II HMG-COA Reductase Inhibitors Part II. Studies Directed Toward the On-Resin Preparation of C-Terminal Modified and Cyclic Peptides. |
| 260 | |
▼a [S.l.] :
▼b Purdue University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 381 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Mark A. Lipton. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Purdue University, 2018. |
| 520 | |
▼a The first part of this dissertation involves the rational design, synthesis and biological evaluation of small molecules targeting Class II HMGR. Inhibitors of this generation were designed based on information derived from the crystal structure |
| 520 | |
▼a The second part of this dissertation summarizes our efforts to contribute new methods for the preparation of C-terminal modified and cyclic peptides on the solid-phase using the backbone amide linker (BAL) approach. To this end, an improved one- |
| 590 | |
▼a School code: 0183. |
| 650 | 4 |
▼a Organic chemistry. |
| 690 | |
▼a 0490 |
| 710 | 20 |
▼a Purdue University.
▼b Chemistry. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0183 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999963
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |