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020 ▼a 9780438371217
035 ▼a (MiAaPQ)AAI10843758
035 ▼a (MiAaPQ)uchicago:14512
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0491 ▼f DP
0820 ▼a 574.191
1001 ▼a Riback, Joshua A. ▼0 (orcid)0000-0002-1516-4484
24510 ▼a Determinants of the Solvent Quality of Water for Disordered Proteins.
260 ▼a [S.l.] : ▼b The University of Chicago., ▼c 2018
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2018
300 ▼a 135 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
500 ▼a Advisers: Tobin R. Sosnick
5021 ▼a Thesis (Ph.D.)--The University of Chicago, 2018.
520 ▼a How sticky are proteins? The solvent quality, or 'stickiness', of a biomolecule has significant implications for function and homeostasis, correct calibration of molecular simulations, engineering and evolution of proteins, and much more. The so
520 ▼a The demonstration that protein demixing benefits organisms is scarce yet examples of conserved demixing are common place. For example upon cellular stress, many proteins demix from the cytosol into observable foci called stress granules. In Chap
520 ▼a Based on this observation, one might expect that the unfolded state of proteins also would similarly act as if it were in a poor solvent. In Chapter 3, I demonstrate that indicate that the P domain is an outlier and that the unfolded states of m
590 ▼a School code: 0330.
650 4 ▼a Biophysics.
650 4 ▼a Molecular biology.
650 4 ▼a Cellular biology.
690 ▼a 0786
690 ▼a 0307
690 ▼a 0379
71020 ▼a The University of Chicago. ▼b Biophysical Sciences.
7730 ▼t Dissertation Abstracts International ▼g 80-01B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0330
791 ▼a Ph.D.
792 ▼a 2018
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999944 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자 ▼b 관리자