| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000330306 |
| 005 | | 20241029095719 |
| 008 | | 181129s2018 ||| | | | eng d |
| 020 | |
▼a 9780438371170 |
| 035 | |
▼a (MiAaPQ)AAI10843117 |
| 035 | |
▼a (MiAaPQ)uchicago:14510 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Dey, Kushal K. |
| 245 | 10 |
▼a Model Based Visualization of Structure in Biological Data. |
| 260 | |
▼a [S.l.] :
▼b The University of Chicago.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 130 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Matthew Stephens. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Chicago, 2018. |
| 520 | |
▼a Biological Data comes in varied forms and the scale of the data is typically large, which often necessitates distinct modeling frameworks and tools to process, analyze and visually summarize the data. An overarching theme of this doctoral thesis |
| 520 | |
▼a The second chapter of this thesis extends the concept of a mixed membership model, popularly known as ADMIXTURE model in population genetics and topic model in Natural Language Processing (NLP), to the context of RNA-sequencing read expression |
| 520 | |
▼a The third chapter extends similar mixed membership models to analyzing DNA damage patterns in ancient DNA (aDNA) samples, and explore and jointly summarize multiple aDNA samples together with modern samples. Applied to a combined data of modern |
| 520 | |
▼a The visual summary of DNA damage patterns, depicted above, includes a version of logo plot that highlights enrichment and depletion of damage features with respect to a background level of mismatch features computed from modern individuals. We c |
| 520 | |
▼a In the fifth chapter, we propose an adaptive method for shrinking correlation matrices that leads to a parsimonious representation of the underlying association structure between variables. This method is flexible in handling data matrices with |
| 590 | |
▼a School code: 0330. |
| 650 | 4 |
▼a Biostatistics. |
| 650 | 4 |
▼a Bioinformatics. |
| 650 | 4 |
▼a Genetics. |
| 690 | |
▼a 0308 |
| 690 | |
▼a 0715 |
| 690 | |
▼a 0369 |
| 710 | 20 |
▼a The University of Chicago.
▼b Statistics. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0330 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999898
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |