| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000330280 |
| 005 | | 20241029094611 |
| 008 | | 181129s2018 ||| | | | eng d |
| 020 | |
▼a 9780438207776 |
| 035 | |
▼a (MiAaPQ)AAI10842833 |
| 035 | |
▼a (MiAaPQ)wisc:15546 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 310 |
| 100 | 1 |
▼a Nguyen, Duy. |
| 245 | 10 |
▼a Statistical Methods for Differential Analysis of Hi-C And ChIP-Seq Data. |
| 260 | |
▼a [S.l.] :
▼b The University of Wisconsin - Madison.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 140 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Sunduz Keles. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2018. |
| 520 | |
▼a High-throughput sequencing has become a standard method in genomics research and made it possible to address important biological questions. In this thesis, we focus on developing statistical methodologies and software to analyze two important h |
| 520 | |
▼a This thesis contains three major parts. In the first part, we discuss challenges in quantitative comparison of Hi-C data (often referred as ``differential (interaction) analysis'' problem) across different cellular conditions. Prior to this work |
| 520 | |
▼a For the second part, we investigate statistical challenges in quantitative comparison of histone profiles across different cellular conditions from ChIP-seq data. Quantitative comparison of histone profiles largely depends on methods borrowed fr |
| 520 | |
▼a In the last part, we describe our two novel software in the R packages TreeHic and tan. Through applications to real Hi-C and ChIP-seq data, we present how these software could reveal biological insights that are not captures in standard data a |
| 590 | |
▼a School code: 0262. |
| 650 | 4 |
▼a Statistics. |
| 650 | 4 |
▼a Biostatistics. |
| 690 | |
▼a 0463 |
| 690 | |
▼a 0308 |
| 710 | 20 |
▼a The University of Wisconsin - Madison.
▼b Statistics. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0262 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999873
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |