| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000330257 |
| 005 | | 20241029092134 |
| 008 | | 181129s2018 ||| | | | eng d |
| 020 | |
▼a 9780438248380 |
| 035 | |
▼a (MiAaPQ)AAI10842429 |
| 035 | |
▼a (MiAaPQ)grad.msu:16204 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 616.01 |
| 100 | 1 |
▼a Corner, Sarah. |
| 245 | 10 |
▼a Ovarian Carcinoma in Jaguars (Panthera onca): Investigating the Genetic Mechanisms of Tumorigenesis. |
| 260 | |
▼a [S.l.] :
▼b Michigan State University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 222 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Dalen Agnew. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Michigan State University, 2018. |
| 520 | |
▼a Jaguars are near threatened throughout their entire geographic range and endangered in the United States. Wild jaguars are threatened by habitat loss and other human impacts, and maintaining a healthy breeding population in zoological institutio |
| 520 | |
▼a We performed a retrospective analysis of reproductive tract and mammary gland lesions from 56 jaguars housed in North American zoological institutions and found a high prevalence (26 of 49 jaguars |
| 520 | |
▼a To elucidate the genetic mechanisms of ovarian carcinoma in jaguars, we first assessed the genetic diversity of the North American zoo population overall compared to reported wild jaguar populations. Using novel universal primer sequences, we cr |
| 520 | |
▼a To evaluate candidate cancer genes for germline mutations associated with ovarian carcinoma, we used a targeted next generation sequencing approach to sequence the coding regions of 276 cancer genes in paired ovarian carcinoma and normal jaguar |
| 590 | |
▼a School code: 0128. |
| 650 | 4 |
▼a Pathology. |
| 650 | 4 |
▼a Oncology. |
| 650 | 4 |
▼a Zoology. |
| 690 | |
▼a 0571 |
| 690 | |
▼a 0992 |
| 690 | |
▼a 0472 |
| 710 | 20 |
▼a Michigan State University.
▼b Pathobiology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0128 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999849
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |