| LDR | | 02275nmm uu200409 4500 |
| 001 | | 000000330179 |
| 005 | | 20240805160028 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438036017 |
| 035 | |
▼a (MiAaPQ)AAI10748763 |
| 035 | |
▼a (MiAaPQ)upenngdas:13128 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 575 |
| 100 | 1 |
▼a Piette, Elizabeth Rachel. |
| 245 | 10 |
▼a Strategies for Improving Epistasis Detection and Replication. |
| 260 | |
▼a [S.l.] :
▼b University of Pennsylvania.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 150 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Jason H. Moore. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Pennsylvania, 2018. |
| 520 | |
▼a Genome-wide association studies (GWAS) have been extensively critiqued for their perceived inability to adequately elucidate the genetic underpinnings of complex disease. Of particular concern is "missing heritability," or the difference between |
| 520 | |
▼a Given our understanding of how biomolecules interact in networks and pathways, it is not unreasonable to conclude that the effect of variation at individual genetic loci may non-additively depend on and should be analyzed in the context of their |
| 520 | |
▼a Current methods for analyzing data from GWAS are not well-equipped to detect epistasis or replicate significant interactions. The multiple testing burden associated with testing each pairwise interaction quickly becomes nearly insurmountable wit |
| 520 | |
▼a Rather than renouncing GWAS and the wealth of associated data that has been accumulated as a failure, I propose the development of new techniques and incorporation of diverse data sources to analyze GWAS data in an epistasis-centric framework. |
| 590 | |
▼a School code: 0175. |
| 650 | 4 |
▼a Genetics. |
| 690 | |
▼a 0369 |
| 710 | 20 |
▼a University of Pennsylvania.
▼b Genomics and Computational Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0175 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14997009
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |