| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000330075 |
| 005 | | 20241023133848 |
| 008 | | 181129s2017 ||| | | | eng d |
| 020 | |
▼a 9780438159679 |
| 035 | |
▼a (MiAaPQ)AAI10690043 |
| 035 | |
▼a (MiAaPQ)wisc:15064 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 576 |
| 100 | 1 |
▼a Barra, Jessica Tse. |
| 245 | 10 |
▼a Understanding (p)ppGpp-mediated Mechanisms of Persistence and Stress Survival in Bacillus subtilis. |
| 260 | |
▼a [S.l.] :
▼b The University of Wisconsin - Madison.,
▼c 2017 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2017 |
| 300 | |
▼a 261 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. |
| 500 | |
▼a Adviser: Jue D. Wang. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2017. |
| 520 | |
▼a During amino acid starvation, the Gram-positive bacterium Bacillus subtilis, produces a molecule called (p)ppGpp, a nucleotide derived from GTP or GDP and ATP. This molecule is produced by almost all bacteria but its effects are best characteriz |
| 520 | |
▼a We examined the role of (p)ppGpp in mediating persistence, the ability of a subpopulation of bacteria to survive antibiotics for a prolonged period of time. We demonstrate that (p)ppGpp is one mechanism of persister formation and is necessary an |
| 520 | |
▼a (p)ppGpp and GTP-dependent mechanisms protect cells against bacteriostatic antibiotics. We treated wild type and (p)ppGpp0 cells with chloramphenicol and saw that (p)ppGpp0 cells lose viability. Interestingly, RelA was the primary (p)ppGpp synth |
| 520 | |
▼a In this work, we comprehensively examined the role of (p)ppGpp in mediating stress survival in persistence. |
| 590 | |
▼a School code: 0262. |
| 650 | 4 |
▼a Microbiology. |
| 690 | |
▼a 0410 |
| 710 | 20 |
▼a The University of Wisconsin - Madison.
▼b Microbiology ALS. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-11B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0262 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996781
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |