| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000330039 |
| 005 | | 20241023112857 |
| 008 | | 181129s2018 ||| | | | eng d |
| 020 | |
▼a 9780438151482 |
| 035 | |
▼a (MiAaPQ)AAI10685245 |
| 035 | |
▼a (MiAaPQ)uiowa:15454 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 615 |
| 100 | 1 |
▼a Bon Durant, Lucas Donald. |
| 245 | 10 |
▼a Regulation of Glucose Homeostasis by FGF21. |
| 260 | |
▼a [S.l.] :
▼b The University of Iowa.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 122 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Matthew J. Potthoff. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Iowa, 2018. |
| 520 | |
▼a Fibroblast Growth Factor 21 (FGF21) is an endocrine hormone derived from the liver that exerts pleiotropic effects on the body to maintain overall metabolic homeostasis. During the past decade, there has been an enormous effort to understand the |
| 520 | |
▼a To address the first goal, we used different FGF21 genetic knockout mouse models to determine if loss of FGF21 would affect macronutrient preference. We found that loss of FGF21 led to an increase in simple sugar intake whereas this had no effec |
| 520 | |
▼a To address the pharmacological actions of FGF21, we generated an adipose-specific KLB KO mouse using mice that express Cre-recombinase under the adiponectin promoter. These mice lack the co-receptor for FGF21 in adipose tissue and are a more rel |
| 590 | |
▼a School code: 0096. |
| 650 | 4 |
▼a Pharmacology. |
| 690 | |
▼a 0419 |
| 710 | 20 |
▼a The University of Iowa.
▼b Molecular & Cell Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0096 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996745
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |