| LDR | | 02161nmm uu200457 4500 |
| 001 | | 000000329968 |
| 005 | | 20240805155623 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780355595222 |
| 035 | |
▼a (MiAaPQ)AAI10638769 |
| 035 | |
▼a (MiAaPQ)washington:17993 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 616.99 |
| 100 | 1 |
▼a Vandeven, Natalie A. |
| 245 | 10 |
▼a Merkel Cell Carcinoma: Immunogenicity and the Characterization of CD4 T Cell Responses to the Merkel Cell Polyomavirus. |
| 260 | |
▼a [S.l.] :
▼b University of Washington.,
▼c 2017 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2017 |
| 300 | |
▼a 194 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-05(E), Section: B. |
| 500 | |
▼a Adviser: Paul Nghiem. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Washington, 2017. |
| 506 | |
▼a This item is not available from ProQuest Dissertations & Theses. |
| 520 | |
▼a Merkel cell carcinoma (MCC) is a deadly, virus-associated skin cancer with a 5-year relative mortality rate of 46%. The Merkel cell polyomavirus (MCPyV) is clonally integrated into 80% of MCCs and persistent expression of MCPyV T-antigen oncopro |
| 520 | |
▼a Within the opening chapters, we explore pathogen-driven cancers more broadly (Chapter 1) before delving specifically into MCPyV-induced MCC, its rising incidence rate (Chapter 2) and known mechanisms of immune evasion (Chapter 3). Previous studi |
| 520 | |
▼a This past year (2017) historically marked the first FDA approval of an agent for the treatment of advanced MCC. Therefore, as we continue to treat more MCC patients with this agent (avelumab |
| 590 | |
▼a School code: 0250. |
| 650 | 4 |
▼a Oncology. |
| 650 | 4 |
▼a Immunology. |
| 650 | 4 |
▼a Pathology. |
| 690 | |
▼a 0992 |
| 690 | |
▼a 0982 |
| 690 | |
▼a 0571 |
| 710 | 20 |
▼a University of Washington.
▼b Pathology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-05B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0250 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996677
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |