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008181129s2017 ||| | | | eng d
020 ▼a 9780355763287
035 ▼a (MiAaPQ)AAI10635842
035 ▼a (MiAaPQ)ucdavis:17402
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0491 ▼f DP
0820 ▼a 636
1001 ▼a Scott, Erica Yuki Azetsu.
24510 ▼a Molecular Pathways Underlying Cerebellar Abiotrophy in Arabian Horses.
260 ▼a [S.l.] : ▼b University of California, Davis., ▼c 2017
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2017
300 ▼a 158 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-08(E), Section: B.
500 ▼a Advisers: James D. Murray
5021 ▼a Thesis (Ph.D.)--University of California, Davis, 2017.
506 ▼a This item is not available from ProQuest Dissertations & Theses.
520 ▼a Cerebellar Abiotrophy is a neurodegenerative disease with an inherited component, resulting in neurodegeneration in the cerebellum. Cerebellar abiotrophy (CA) affects Arabian horses and results in an ataxic phenotype involving uncoordinated limb
520 ▼a The uncertainty revolving around the ramifications of the CA-associated SNP on the candidate genes and crucial pathways in the cerebellum drove us to investigate the transcriptome-wide differences between healthy and CA-affected horses. Pathways
520 ▼a Total RNA sequencing (RNA-seq) suggested differential MUTYH isoform usage in CA-affected horses. We confirmed this using more targeted approaches of quantifying mRNA expression and uncovered differential MUTYH promoter usage as well as MUTYH pro
590 ▼a School code: 0029.
650 4 ▼a Animal sciences.
650 4 ▼a Animal diseases.
650 4 ▼a Neurosciences.
690 ▼a 0475
690 ▼a 0476
690 ▼a 0317
71020 ▼a University of California, Davis. ▼b Animal Biology.
7730 ▼t Dissertation Abstracts International ▼g 79-08B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0029
791 ▼a Ph.D.
792 ▼a 2017
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996670 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자 ▼b 관리자