| LDR | | 02186nmm uu200409 4500 |
| 001 | | 000000329961 |
| 005 | | 20240805155615 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780355591095 |
| 035 | |
▼a (MiAaPQ)AAI10636570 |
| 035 | |
▼a (MiAaPQ)umaryland:10901 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 615 |
| 100 | 1 |
▼a Boyce, Heather J. |
| 245 | 10 |
▼a Mechanistic Evaluation of Polyethylene Oxide for Physical Barrier Type Abuse Deterrent Formulations: Techniques and In Vitro Methods. |
| 260 | |
▼a [S.l.] :
▼b University of Maryland, Baltimore.,
▼c 2017 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2017 |
| 300 | |
▼a 256 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-05(E), Section: B. |
| 500 | |
▼a Adviser: Stephen W. Hoag. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Maryland, Baltimore, 2017. |
| 506 | |
▼a This item is not available from ProQuest Dissertations & Theses. |
| 520 | |
▼a Abuse deterrent formulations (ADF) are designed to mitigate misuse and abuse of prescription narcotics. One mechanism of an ADF is to increase the tablet strength to reduce ease of tablet comminution while increasing the difficulty of drug extra |
| 520 | |
▼a Key results of this study show that heating tablets with PEO will significantly increase the strength of the tablet and key variables such as PEO composition, particle size distribution, high initial tablet solid fraction, and 1 h sinter time we |
| 520 | |
▼a Finally, the in vitro nasal insufflation studies demonstrated that for each type of physical manipulation employed (i.e. cutting, grinding, milling), discreet particle size distributions were formed regardless of formulation. One exception occur |
| 590 | |
▼a School code: 0373. |
| 650 | 4 |
▼a Pharmaceutical sciences. |
| 690 | |
▼a 0572 |
| 710 | 20 |
▼a University of Maryland, Baltimore.
▼b Pharmaceutical Sciences. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-05B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0373 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996671
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |