| LDR | | 02301nmm uu200433 4500 |
| 001 | | 000000329892 |
| 005 | | 20240805155455 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438050563 |
| 035 | |
▼a (MiAaPQ)AAI10824553 |
| 035 | |
▼a (MiAaPQ)princeton:12638 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 610 |
| 100 | 1 |
▼a Simi, Allison K. |
| 245 | 10 |
▼a Mechanical Regulation of Genomic Instability in Cancer. |
| 260 | |
▼a [S.l.] :
▼b Princeton University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 127 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Celeste M. Nelson. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Princeton University, 2018. |
| 520 | |
▼a It is expected that 1 in 3 people in the United States will develop cancer in their lifetime, and it remains the second leading cause of death worldwide. The research that drove most current cancer therapies focused primarily on the cancer cells |
| 520 | |
▼a We found that increased stiffness induces multinucleation, regulated in part by signaling downstream of matrix metalloproteinase-3 (MMP 3). MMP3 is commonly upregulated in cancer and known to induce epithelial-mesenchymal transition (EMT), a pro |
| 520 | |
▼a Following these findings, we investigated the specific mechanisms by which stiffness and EMT signaling induce multinucleation. We found that elevated levels of septin-6, a novel target of Snail, results in midbody persistence, abscission failure |
| 520 | |
▼a Taken together, these data suggest that tissue stiffening during tumorigenesis synergizes with oncogenic signaling to promote genomic abnormalities that drive cancer progression, and provide the first evidence that mechanical stiffness of the mi |
| 590 | |
▼a School code: 0181. |
| 650 | 4 |
▼a Bioengineering. |
| 650 | 4 |
▼a Oncology. |
| 690 | |
▼a 0202 |
| 690 | |
▼a 0992 |
| 710 | 20 |
▼a Princeton University.
▼b Chemical and Biological Engineering. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0181 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998675
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |