| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000329785 |
| 005 | | 20241016151504 |
| 008 | | 181129s2018 ||| | | | eng d |
| 020 | |
▼a 9780438065741 |
| 035 | |
▼a (MiAaPQ)AAI10823072 |
| 035 | |
▼a (MiAaPQ)unc:17912 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 615 |
| 100 | 1 |
▼a Okumu, Denis O. |
| 245 | 10 |
▼a LYN Regulates Drug Resistance Mechanisms in Chronic Myelogenous Leukemia (CML). |
| 260 | |
▼a [S.l.] :
▼b The University of North Carolina at Chapel Hill.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 135 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Advisers: Lee M. Graves |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018. |
| 520 | |
▼a Acquired resistance to anti-cancer therapy presents a critical challenge to effective clinical management of chronic myelogenous leukemia (CML). Drug-resistant CML cells devise diverse molecular adaptations to evade therapy. Examples of such ada |
| 520 | |
▼a In the first project, I showed that increased Lyn expression and activity in Myl-R cells up-regulated the expression and stability of BIRC6, a member of the inhibitor of apoptosis proteins (IAP) family known to bind and inactivate active caspase |
| 520 | |
▼a In the second project, I am investigating Lyn's role in regulating creatine uptake by Myl-R cells. Our lab previously showed that total intracellular creatine pool was 5-fold higher in Myl-R than Myl cells. Our unpublished data show that the inc |
| 520 | |
▼a Taken together, these studies enrich our understanding of the diverse therapy-survival mechanisms utilized by CML cells, and provide insights into novel targets for effective cure of CML. |
| 590 | |
▼a School code: 0153. |
| 650 | 4 |
▼a Pharmacology. |
| 690 | |
▼a 0419 |
| 710 | 20 |
▼a The University of North Carolina at Chapel Hill.
▼b Pharmacology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0153 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998539
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |