| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000329744 |
| 005 | | 20241016150638 |
| 008 | | 181129s2018 ||| | | | eng d |
| 020 | |
▼a 9780438065727 |
| 035 | |
▼a (MiAaPQ)AAI10822692 |
| 035 | |
▼a (MiAaPQ)unc:17910 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 614.4 |
| 100 | 1 |
▼a Breskin, Alexander Samuel. |
| 245 | 14 |
▼a The Effects of Hepatitis C Infection, Treatment, and Population Interventions on All-Cause Mortality Among People Living with HIV. |
| 260 | |
▼a [S.l.] :
▼b The University of North Carolina at Chapel Hill.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 180 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. |
| 500 | |
▼a Adviser: Daniel Westreich. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018. |
| 520 | |
▼a Approximately 25% of people living with HIV (PLWH) in the United States are co-infected with hepatitis C virus (HCV), which, if left untreated, causes mortality through decompensated cirrhosis and hepatocellular carcinoma. Direct-acting antivira |
| 520 | |
▼a Using data from 3,056 PLWH in the Women's Interagency HIV Study and Multicenter AIDS Cohort Study from 1994 to 2015, we used the parametric g-formula to estimate the effects of HCV infection and DAA treatment on 10-year all-cause mortality. We a |
| 520 | |
▼a The estimated 10-year mortality risk difference (RD) for HCV infection was 4.3% (95% CI: 0.4%, 8.9%). The RD for DAA treatment was -3.7% (95%CI: -9.1%, 0.6%). The RD for treating those with HIV suppression and severe fibrosis or cirrhosis was -1 |
| 520 | |
▼a These results show that HCV is a major cause of mortality among PLWH, and that DAA treatment is effective at reducing mortality in this population. They also suggest that common DAA access criteria may be suboptimal and expanding access to these |
| 590 | |
▼a School code: 0153. |
| 650 | 4 |
▼a Epidemiology. |
| 650 | 4 |
▼a Biostatistics. |
| 690 | |
▼a 0766 |
| 690 | |
▼a 0308 |
| 710 | 20 |
▼a The University of North Carolina at Chapel Hill.
▼b Epidemiology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-11B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0153 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998499
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |