| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000329739 |
| 005 | | 20241016150503 |
| 008 | | 181129s2018 ||| | | | eng d |
| 020 | |
▼a 9780438048652 |
| 035 | |
▼a (MiAaPQ)AAI10822647 |
| 035 | |
▼a (MiAaPQ)princeton:12567 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 660 |
| 100 | 1 |
▼a Pagels, Robert F. |
| 245 | 10 |
▼a Polymeric Nanoparticles and Microparticles for the Delivery of Hydrophobic and Hydrophilic Therapeutics. |
| 260 | |
▼a [S.l.] :
▼b Princeton University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 405 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Robert K. Prud'homme. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Princeton University, 2018. |
| 506 | |
▼a This item is not available from ProQuest Dissertations & Theses. |
| 520 | |
▼a Polymeric particle formulations can improve the therapeutic performance of two distinct drug classes: hydrophobic small molecules and hydrophilic biologic macromolecules. Nanoparticle formulations of hydrophobic drugs can increase the dissolutio |
| 520 | |
▼a The work presented herein applies the Flash NanoPrecipitation (FNP) process to the formulation of both water-insoluble (Part I) and water-soluble (Part II) materials. FNP has traditionally been used to produce nanoparticles of hydrophobic therap |
| 520 | |
▼a In Part II, the FNP process was inverted (iFNP) to allow for the encapsulation of hydrophilic molecules. The new iFNP process was demonstrated on a variety of model drugs, and the methods to control nanoparticle size were established. The result |
| 520 | |
▼a In summary, this dissertation expands the applicability of the FNP platform technology, enabling new nanoparticle and microparticle formulations of therapeutics. |
| 590 | |
▼a School code: 0181. |
| 650 | 4 |
▼a Chemical engineering. |
| 650 | 4 |
▼a Nanoscience. |
| 650 | 4 |
▼a Polymer chemistry. |
| 690 | |
▼a 0542 |
| 690 | |
▼a 0565 |
| 690 | |
▼a 0495 |
| 710 | 20 |
▼a Princeton University.
▼b Chemical and Biological Engineering. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0181 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998494
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |