| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000329735 |
| 005 | | 20241016150328 |
| 008 | | 181129s2018 ||| | | | eng d |
| 020 | |
▼a 9780438048584 |
| 035 | |
▼a (MiAaPQ)AAI10822547 |
| 035 | |
▼a (MiAaPQ)princeton:12561 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Hall, Allison Elizabeth. |
| 245 | 10 |
▼a Positive and Negative Regulation of Cell Fusion in Saccharomyces cerevisiae. |
| 260 | |
▼a [S.l.] :
▼b Princeton University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 166 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Mark D. Rose. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Princeton University, 2018. |
| 520 | |
▼a Cell fusion is ubiquitous in eukaryotic organisms. Saccharomyces cerevisiae cells fuse during mating |
| 520 | |
▼a The highly conserved Rho-GTPase, Cdc42p, functions in polarized growth during pheromone response and prezygote formation. Cdc42p binds the heterodimer amphiphysin, Fus2p/Rvs161p, facilitating cell wall degradation. Cdc42p is recruited to a focus |
| 520 | |
▼a A hyperactive component of the cell wall integrity (CWI) pathway, Pkc1p (PKC1*), causes a cell fusion defect, suggesting a negative regulatory role in cell fusion. The cell wall is monitored by five transmembrane proteins, Wsc1-3p, Mid2p, and Mt |
| 520 | |
▼a In the course of these studies, we found that WSC1 has a zygote/diploid specific role differing from the role of MID2. Diploids die at a high rate without WSC1, due to cell lysis during budding. These differences underscore the distinct function |
| 590 | |
▼a School code: 0181. |
| 650 | 4 |
▼a Molecular biology. |
| 650 | 4 |
▼a Cellular biology. |
| 650 | 4 |
▼a Genetics. |
| 690 | |
▼a 0307 |
| 690 | |
▼a 0379 |
| 690 | |
▼a 0369 |
| 710 | 20 |
▼a Princeton University.
▼b Molecular Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0181 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998486
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |